Seth Gecko and his younger brother Richard are on the run after a bloody bank robbery in Texas. They escape across the border into Mexico and will be home-free the next morning, when they pay off the local kingpin. They just have to survive 'from dusk till dawn' at the rendezvous point, which turns out to be a Hell of a strip joint.
A burger-loving hit man, his philosophical partner, a drug-addled gangster's moll and a washed-up boxer converge in this sprawling, comedic crime caper. Their adventures unfurl in three stories that ingeniously trip back and forth in time.
Writer Paul Benjamin is nearly hit by a bus when he leaves Auggie Wren's smoke shop. Stranger Rashid Cole saves his life, and soon middle-aged Paul tells homeless Rashid that he wouldn't mind a short-term housemate. Still grieving over his wife's murder, Paul is moved by both Rashid's quest to reconnect with his father and Auggie's discovery that a woman who might be his daughter is about to give birth.
A Reno singer witnesses a mob murder and the cops stash her in a nunnery to protect her from the mob's hitmen. The mother superior does not trust her, and takes steps to limit her influence on the other nuns. Eventually the singer rescues the failing choir and begins helping with community projects, which gets her an interview on TV—and identification by the mob.
In the midst of World War II, the battle under the sea rages and the Nazis have the upper hand as the Allies are unable to crack their war codes. However, after a wrecked U-boat sends out an SOS signal, the Allies realise this is their chance to seize the 'enigma coding machine'.
A botched robbery indicates a police informant, and the pressure mounts in the aftermath at a warehouse. Crime begets violence as the survivors -- veteran Mr. White, newcomer Mr. Orange, psychopathic parolee Mr. Blonde, bickering weasel Mr. Pink and Nice Guy Eddie -- unravel.